The safety of Enzymatically Modified Isoquercitrin has been found safe in many toxicity studies and has been self-affirmed as Generally Recognized as Safe (GRAS) by FDA (GRAS Notice No.GRN000220).
U.S., Canada, Japan
Intake of Enzymatically Modified Isoquercitrin can improve vascular function.
Dose：Enzymatically Modified Isoquercitrin 293 mg/60 kg body weight
Subjects：25 volunteers at risk of cardiovascular disease
Evaluation： FMD (Flow-mediated dilatation)
<K. Croft et al., Br. J. Nutri., 20, 1-8, 2019, https://doi.org/10.1017/S0007114519002137>
Intake of Enzymatically Modified Isoquercitrin can reduce the hay fever symptoms.
Dose： Enzymatically Modified Isoquercitrin 100 mg/day
Subjects： 20 volunteers with Japanese cedar pollinosis
Administration period： 8 weeks
Evaluation：Symptom score (sneezing, runny nose, nasal obstruction,
lacrimation, redness and itching of the eyes)
<M. Kawai et al., Int. Arch. Allegy Immunol., 149, 359-368, 2009, https://doi.org/10.1159/000205582>
Intake of chewing gum containing Enzymatically Modified Isoquercitrin can promote
Dose： Chewing gum containing 1.4 mg Enzymatically Modified Isoquercitrin
Subjects：3 healty volunteers
Evaluation：The amount of saliva secretion
<Patent filing:WO2017/094910 A1 >
In humans, Enzymatically Modified Isoquercitrin is 17 times more bioavailable than quercetin.
<Modified from K. Murota, et al., Arch. of Biophysics, 501, 91-97, 2010, https://doi.org/10.1016/j.abb.2010.06.036>